A recent study reveals that people who stop using new weight-loss injections like semaglutide or tirzepatide may regain lost weight at a significantly accelerated pace than those who halt conventional lifestyle regimens.
Research printed in a major medical journal points out that while overweight people often shed substantial amounts of their total mass while on the medication, the weight returns at an estimated rate of nearly a kilo each month upon discontinuation.
"People using these medications must be informed of the danger of quick weight regain when the treatment is stopped," stated expert Dr. Susan Jebb.
This pace of recovery implies a return to starting mass within about one and a half years.
Weighing Treatments
The research, which reviewed dozens of trials involving over 9,000 of participants, compared the outcomes of these new drugs with other pills.
Researchers point out that individuals who shed pounds through lifestyle changes alone typically have a more gradual creep back—approximately 0.1 kg a month—once they finish.
Explaining the Quick Rebound
Nutrition scientists propose the mechanism of the jabs is key to understanding the accelerated rebound.
These medications copy a natural hormone called GLP-1, which helps regulate hunger.
"Long-term administration of GLP-1 levels several times higher than normal may cause the system to produce less of its endogenous hormone, and may also diminish responsiveness to its effects," noted Dr. Adam Collins, a dietetics expert.
"Withdrawal of this GLP-1 'fix' leads to appetite is unsuppressed, making binge eating a significant risk."
A Lifelong Condition?
The NHS suggest the injections for individuals with obesity-related medical conditions, alongside recommended lifestyle changes.
Many experts argue that, due to the likelihood of relapse, the therapy might need to be long-term.
This opinion is supported by drug manufacturers, who say that the findings "emphasize the long-term nature of excess weight," similar to managing conditions like high blood pressure.
User Experiences
People who have stopped the jabs describe a powerful return of appetite.
"It was like a trigger that goes on and you're instantly extremely hungry," recalled a patient.
This challenge is worsened if individuals have not adopted sustainable lifestyle or habit changes during treatment.
Growing Use
Figures indicate that millions of people in the UK have tried these injections in the past year, with demand continuing to grow.
- Use is more common among women than men.
- The middle-aged demographic shows the highest level of interest.
- Many access the medications through private prescriptions rather than the NHS.
In conclusion, researchers emphasize that while these medications are effective agents for weight loss, they are not a magic cure and lasting health benefits likely depends on ongoing lifestyle support.
